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Year : 2018  |  Volume : 5  |  Issue : 2  |  Page : 55-57

Features of acid–base balance of bone marrow

Prof. Dyhno, Department of Surgical Conditions with Courses in Endoscopy and Endosurgery, Krasnoyarsk State Medical University, Krasnoyarsk, Russia

Correspondence Address:
Mrs. Lyudmila P Nikolaeva
Ulitsa Partizana Zhelesnyaka, 1, Krasnoyarsk, 660022
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ami.ami_80_17

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Context: Bone marrow (BM) pH has rarely been measured, and the long BM has barely been studied at all because intravital obtaining of the long BM is impossible due to the extreme strength of the long bone tissue. Aims: The study aimed to investigate the acid–base balance of the BM and to compare the acid–base properties of long BM and flat BM. Subjects and Methods: Forty flat BM samples were extracted by sternal puncture. Forty long BM samples were extracted from the femora in patients who had to have a limb amputated. A blood gas and acid–base status analyzer were used to determine pH. Results: Flat BM pH is similar to blood p; the long BM pH is acidic and ranges from 6.7 to 6.9. Hematopoietic stem cells occur in both acidic and slightly alkaline environments. The blood gas and acid–base status analyzer used in this study are suitable for determining the acid–base properties of BM. Conclusions: The acid–base status appears to be an important factor of stem cell differentiation. This paper can be of interest to biotechnologists and researchers who investigate possibilities to influence the differentiation and properties of the stem cells.

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