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Year : 2015  |  Volume : 2  |  Issue : 2  |  Page : 143-148

Narrative review: Genetic findings in patients of generalized anxiety disorder

1 Senior Instructor (Research), Department of Medicine, Aga Khan University Hospital, Pakistan
2 Consultant Psychiatrist, Department of Psychiatry, Liaquat National Hospital, Pakistan

Correspondence Address:
Afshan Channa
Consultant Psychiatrist, Department of Psychiatry, Liaquat National Hospital
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Source of Support: None, Conflict of Interest: None

DOI: 10.5530/ami.2015.4.6

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General anxiety disorder is a chronic disorder. The prevalence of GAD is variable in different part of world, with some region having higher figure than others. It's uncertain to quote if the variation is due to genetic loading or environmental factors. It is twice more common in females than males. It has constituted substantial burden on global economy as well as over all quality of life of an individual suffering from GAD. The prognosis of GAD is mainly correlated with the environmental constraints. However, the efficacy of response to pharmacological intervention is better explained on biological model. Certain studies are done to widen the ground of genesis of GAD. Although, by and large it still remains debatable about distinctive gene causing GAD. Nonetheless, the alteration of gene coding of 5-HTTLPR of serotonin is relatively favorable finding in studies, both independently done on GAD and in parallel to other anxiety disorders and psychiatric morbidities.

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