Cytotherapy for Osteonecrosis of Hip

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Acta Medica International,2014,1,1,36-38.
Published:January 2014
Type:Review Article

Cytotherapy for Osteonecrosis of Hip

Najmul Huda1, Asif Iqbal2, Ajay Pant3, M Julfiqar2, Nitin Kumar Agarwal2, Pankaj Gupta4

1Associate Professor, 2Assistant Professor, 3Professor and Head, 4Senior Resident, Department of Orthopaedics, Teerthanker Mahaveer Medical College and Research Centre, Moradabad U.P., India

Abstract:

Osteonecrosis of hip is a pathological condition that leads to collapse of the femoral head, & the need for total hip replacement (THR). Research has shown that at the cellular level there is decrease in osteoblastic activity & the local mesenchymal stem cells (MSC) population that leads to osteonecrosis of femoral head (ONFH). Cellular therapy could thus be used to improve the local cellular environment. This can be achieved by implanting bone marrow, containing osteogenic precursors into the necrotic lesion of the femoral head.