Pretreatment with Myo-Inositol in Patients Undergoing Gonadotropins Multiple Follicular Stimulation for IVF
Myo-inositol is an isomer of a C6 sugar alcohol that belongs to the vitamin B complex group. Myo-inositol (MI) is one of the nine isomeric forms of inositol present in nature and can be synthesized by the body in the follicular microenvironment; various natural forms of inositol also exist, among which the most studied is the D-chiro-inositol (DCI), which is not synthesized from precursors in the body but obtained from epimerization of Myo Inositol. In stereochemistry, epimer refers to one of a pair of stereoisomers. The two isomers differ in configuration at only one stereogenic center. All other stereocenters in the molecules, if any, are the same in each. Epimerisation is a chemical process where an epimer is transformed into its chiral counterpart.Biochemical studies have shown that the Myo Inositol (MI) stereoisomers are specifically involved in the correct activation of the insulin receptor as well as in the transduction of the message (second messenger) able to activate intracellular metabolic processes of glycolysis. Read more. . .