Outcomes of GnRH Agonist and GnRH Antagonist Regimens for IVF in Women Aged up to 40

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Acta Medica International,2016,3,1,46-49.
Published:January 2016
Type:Original Article

Outcomes of GnRH Agonist and GnRH Antagonist Regimens for IVF in Women Aged up to 40

Érika Vieira de Souza Jordão1, Hitomi Miura Nakagawa1, Flavielly Souza Estrela1, Raiene Barbosa de Morais1, David Barreira Gomes-Sobrinho1, Bruno Ramalho de Carvalho1

1GENESIS – Center for Assistance in Human Reproduction, Brasília, Distrito Federal, Brazil


Objective: To compare outcomes among good-prognosis patients undergoing in vitro fertilization and intracytoplasmic sperm injection followed by embryo transfer (IVF/ ICSI-ET) in GnRH-agonist (GnRH-a) and GnRH-antagonist (GnRH-ant) regimens. Methods: Retrospective analysis of 434 IVF/ICSI-ET cycles performed in a private center, in women aged up to 40: GnRH-a (n = 291) and GnRH-ant (n = 143). Pregestational, gestational and perinatal outcomes were evaluated. Statistical analysis was performed by unpaired t-test, Mann-Whitney test and Fisher’s exact test. Significance was set at p < 0.05. Results: GnRH-a regimen was associated with higher amounts of total oocytes (10.7 ± 5.7 vs 9.3 ± 5.7, p < 0.001), mature oocytes (8.2 ± 4,5 vs 6.8 ± 4.4, p < 0.001) and good quality embryos transferred (1.7 ± 0.8 vs 1.5 ± 0.9; p < 0.05). Rates of fertilization, embryo implantation and live births were also higher in GnRH-a (72.8%, 27.6% and 48.8%, respectively) compared to GnRH-ant (65.3%, 14.7% and 26.6%, respectively; p < 0.0001). There were no significant differences between rates of preterm delivery or low birth weight, comparing the two groups. Conclusion: Our results suggest that the long GnRH-a regimen is the one that offers the best reproductive outcomes among in women aged up to 40 undergoing IVF/ICSI-ET.

Érika Vieira de Souza Jordãol