A Clinical Study to Compare Hyponatremia Induced By the Use of Two Different Tricyclic Antidepressants – Amitriptyline and Imipramine

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Acta Medica International,2017,4,1,40-42.
Published:November 2016
Type:Original Article

A Clinical Study to Compare Hyponatremia Induced By the Use of Two Different Tricyclic Antidepressants – Amitriptyline and Imipramine

Seema Singh Parmar1, P. B. Behere2
 
1Department of Psychiatry, Teerthanker Mahaveer Medical College & Research Centre, Moradabad – 244001, India.
 
2Department of Psychiatry, Director of (R&D) Datta Meghe Institute of Medical Sciences, Sawangi, Wardha – 442 004, India

Abstract:

Aims & Objectives: To compare the occurrence of hyponatremia in the patients receiving two different Tricyclic Antidepressants (TCAs)–Amitriptyline and Imipramine Methodology: Fifty OPD patients attending the Psychiatry outpatient clinic of Mahatma Gandhi Institute of Medical Sciences, Sewagram having diagnosis of Depressive episode as per DSM-IV-TR criteria were included in the study. Patients with normal serum sodium levels before treatment with antidepressant were included in the study. Repeat serum Sodium levels were done after one month of being on treatment. EPI Info-6 software was used to analyze the data. Results: Average serum sodium concentrations of the patients receiving different TCAs before treatment were 139.4+2.45 (Mean+SD). Out of the 44% patients who developed hyponatremia, 45.45% were amongst the Imipramine group and 54.54% were amongst the Amitriptyline group. Although of mild severity only, hyponatremia was more in patients receiving Amitriptyline compared to those receiving Imipramine. Conclusion: Patients receiving Amitriptyline have fairly more chance of developing hyponatremia than Imipramine receiving patients. Hence precaution should be observed while using TCA group of antidepressants.

Chart showing development of hyponatremia with TCAs