Strategy Planning for Shortening the List of the Metabolic Syndrome Candidate Genes
Most diseases involve many genes in complex interactions, in addition to environmental influences. The genetic susceptibility to a particular disease due to the presence of one or more gene mutations, and/or a combination of alleles need not necessarily be abnormal. Understanding genetic predisposition to disease and knowledge of lifestyle modifications that either exacerbates the condition or that lessen the potential for diseases is necessary for the societies to make informed choices. The aim of this narrative review is to identify an optimal candidate gene and its single nucleotide polymorphism in metabolic syndrome. The prevalence of non-communicable disorders such as metabolic syndrome (MetS) is high in developing countries such as Iran. The Tehran Lipid and Glucose Study (TLGS) was one of the first studies reporting this high incidence. The present review aims to discover the genetic variant reported in association with MetS. The database for genotypes and phenotypes (dbGaP) and the database for genetic associations and human genome (HuGE navigator) were utilized in order to search for genes and their corresponding polymorphisms related to MetS. Additionally, an electronic literature search for other Iranian studies and the genetic aspect of TLGS was completed using PubMed. The results distinguished six of the most important genetic regions found to have strong association with MetS.