Genetic and Clinical Aspects of Brugada Syndrome

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Acta Medica International,2015,2,2,112-117.
Published:July 2015
Type:Review Article

Genetic and Clinical Aspects of Brugada Syndrome

Laila Anjuman Banu1, Rifat Ara Najnin2

1Department of Genetic and Molecular Biology, Faculty of Basic Medical and Paraclinical Sciences, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh,

2Scientific Officer, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh


Death is always dreadful and the diseases those causes sudden death are universal threats in health concern. Brugada syndrom is a recently identified entity of arrhythmia and sudden cardiac death. This genetic and male dominant disorder is prevalent in Southeast Asian region. At least seven genes have been identified to associate with its occurrence though the detail pathophysiological mechanism is till to be resolved. The correlation of ion channel genes to Brugada syndrom is still dubious as the same genes also related to other cardiac diseases. Here we review the genetic aspects of Brugada syndrom with a breif overview of epidemiology, diagnosis and management system.