Larynx Preservation Rate in Laryngeal Cancer Patients Treated with Chemotherapy and Radiotherapy: An Institutional Review of 250 Patients

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Acta Medica International,2016,3,2,141-145.
Published:September 2016
Type:Original Article

Larynx Preservation Rate in Laryngeal Cancer Patients Treated with Chemotherapy and Radiotherapy: An Institutional Review of 250 Patients

Sumit Goyal1, Pooja Nandwani Patel2, Mehul Gohil2, U. Suryanarayana3

1Junior Lecturer, Department of Radiation Oncology, Gujarat Cancer and Research Institute, Ahmadabad, Gujarat, India,

2Associate Professor, Department of Radiation Oncology, Gujarat Cancer and Research Institute, Ahmadabad, Gujarat, India,

3Professor and Head, Department of Radiotherapy, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India

Abstract:

Introduction: Chemo-radiation preceded by induction chemotherapy is reported valuable alternative to laryngectomy in laryngeal cancer for larynx preservation.This study was performed to assess the influence chemo radiation on preservation of larynx.

Materials and Methods: Two hundred and fifty sequential patients treated from January 2012 to December 2012 in our institute were reviewed and who were available for follow-up in this retrospective study. Total dose of 66-70 Gray was used at 2 gray per fraction daily for five days week were used. Larynx preservation rate at3 years of median follow-up were analyzed.

Results: Among 250 patients, larynx preservation was possible in 170 patients (68%). With chemo-radiation, excellent preservation of larynx was achieved in stage II (78%) disease, while in advanced stage III and stage IVA, larynx preservation was67.06% and 64.35%, respectively.

Conclusion: Chemo-radiation (either neoadjuvant chemotherapy followed by chemoradiation or concurrent chemo-radiation) has better larynx preservation rate in early as well was advanced laryngeal cancer patients.

Skiagram showing 2D portal for laryngeal cancer patient