Serum HSP27 Antibody Titers in Patients with Alzheimer’s Disease and Vascular Dementia

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Acta Medica International,2016,3,2,56-60.
Published:September 2016
Type:Original Article

Serum HSP27 Antibody Titers in Patients with Alzheimer’s Disease and Vascular Dementia

Mohammad Kiani1, Naghmeh Mokhber2, Majid Ghayour Mobarhan3, Lida Jarrahi4, Mohammad Reza Najarzadegan5, Elham Ataei6, Mehdi Rahimpour7, Farzad Akbarzadeh8

1Resident of Psychiatry, Psychiatry and Behavioral Sciences Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran,

2Professor of Psychiatry, Psychiatry and Behavioral Sciences Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran,

3Associate Professor of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran,

4Assistant Professor of Social Medicine, Faculty of Community Medicine, Mashhad University of Medical Sciences, Mashhad, Iran,

5Resident of Psychiatry, Tehran Institute of Psychiatry, Faculty of Behavioral Sciences and Mental Health, Iran University of Medical Sciences, Tehran, Iran,

6Neurologist, Khatamolanbia Hospital, Iranshahr University of Medical Sciences, Iranshahr, Iran,

7Biological Chemistry Department, Medical School, University of Michigan, Ann Arbor, USA,

8Assistant Professor of Psychiatry, Psychiatry and Behavioral Sciences Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract:

Introduction: It is possible that immunological factors, including the heat shock protein family, are involved in the development of the different forms of dementia. We aimed to compare the levels of serum HSP27 in patients with Alzheimer’s disease and vascular dementia.

Materials and Methods: Thirty patients with grade 2 Alzheimer’s disease, 30 patients with grade 2 vascular dementia and 30 normal subjects as a control group were recruited during November 2011 to November 2013. Diagnoses were based on DSM-IV-TR criteria. MMSE was conducted on all patients for assessing the severity of disease. Biochemical parameters, including HSP27 were measured in all subjects. Demographic characteristics were collected for all subjects.

Results: There were no statistically significant differences in age, gender and the levels of HSP27 between males and females in all groups. However there was a significant association between HSP27 with the severity and duration of dementia in patients groups. HSP27 levels were lower in the vascular dementia compared to those with Alzheimer’s dementia, but were higher than for controls.

Conclusion: HSP27 antibody titers were positively related to the severity and duration of both Alzheimer’s and vascular dementia and may be indicative of the role of this protein in the pathology of dementia.

Mohammad Reza Najarzadegan