A Case of dic (1:15) (p11;p11) with t(9:22) (q34:q11) in B-ALL

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Acta Medica International,2015,2,2,189-190.
Published:July 2015
Type:Case Report

A Case of dic (1:15) (p11;p11) with t(9:22) (q34:q11) in B-ALL

Anitha Saminathan1, Prabhu2, Indhumathi Nagarathinam3

1Senior Technologist, Central Molecular Diagnostic Lab & Cytogenetics, Laboratory Services, Apollo Main Hospitals, Chennai, India,

2Senior Consultant, Clinical Hematology, Apollo Main Hospitals, Chennai, India,

3Geneticist, Central Molecular Diagnostic Lab & Cytogenetics, Laboratory Services, Apollo Main Hospitals, Chennai, India - 600 006

Abstract:

B cell ALL is a subtype of Acute lymphoblastic leukemia (ALL). Till date, 3 dicentric’s: dic (7;9), dic(9;12) and dic(9;20) with t(9;22) were reported in B- ALL . The hematological profile revealed a white blood cell count of 324.3 X10³/mm3 with 74% blasts, a hemoglobin level of 6.2 g/dl and a platelet count of 50X109 /mm. Trephine biopsy revealed proliferations of blasts which are medium sized to large and had vesicular nuclei with indented nucleoli. The biochemical parameters were normal except elevated liver AST (67U/L);ALT(121U/L);GGTP(159U/L), alkaline phosphatase (251U/L) profiles and renal urea (46mg/dl),Creatinine (1.446mg/dl) and sodium (135mEq/L). The patient was positive for the Immunophenotypic markers CD10/CD19/CD34/ CD33 by Flowcytometry. Diagnosis of B- ALL was made. To our knowledge this dic(1;15)(p11:p11) with t(9;22) (q34;q11) is the first kind of report in B-ALL. Further molecular studies are required to elucidate the pathogenesis and prognostic significance of dic(1;15) in leukemia.

GTG banded karyogram exhibiting 46,XY,+1,dic(1;15)(p11;p11),t(9;22) Figure 2: Partial Karyotype of dic(1;15).t(9;22) (q34;q11)