Quantifying Environmental Risk Factors for Multiple Sclerosis in Discordant Monozygotic Twins: A Case Report

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Acta Medica International,2015,2,2,178-181.
Published:July 2015
Type:Case Report

Quantifying Environmental Risk Factors for Multiple Sclerosis in Discordant Monozygotic Twins: A Case Report

Mohammad Reza Jabalameli1, Seyed Amir Bahreini2, Fereshteh Ashtari3, Hamid Zahednasab4

1Postgraduate Researcher, Human Genetics and Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK,

2Postgraduate Researcher, Department of Human Genetics, Graduate School of Public Health, University
of Pittsburgh, Pittsburgh, PA, USA,

3Associate Professor, Department of Neurology, Isfahan Neurological Sciences Research Centre, Isfahan Medical Education Research Center, Isfahan University of Medical Sciences, Isfahan, Iran,

4Postgraduate Researcher, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran

Abstract:

Relative contribution of genetic and environmental risk factors in complex disorders is widely explored through discordant identical twins. Multiple sclerosis is a demyelinating disease of the central nervous system in which the interplay of genetic and environmental risk factors define the disease pathogenicity. Robust epidemiological studies in different populations suggested that active levels of serum vitamin D and viral load implicate in MS pathogenicity and severity. In order to refine non-shared components of susceptibility factors in MS, we investigated the role of serum 25-hydroxyvitamin D and viral infection in a pair of identical twins remained discordant for MS during the course of 5 years follow up. Here we report serological finding regarding the viral load and serum 25-hydroxyvitamin D level in a pair of discordant monozygotic twins. Based on our observation, lower levels of serum 25-hydroxyvitamin D and higher anti-viral IgG titre was consistent with the disease statues in the affected sib.

Pedigree of subject family