Fluoxetine Associated with Seizure: A Case Report
Introduction: Fluoxetine is a selective serotonin reuptake inhibitor (SSRI). It is licensed for the treatment of depression, obsessive-compulsive disorder and bulimia nervosa. It is thought to have a low adverse effect profile compared to conventional tricyclic antidepressants (TCA). It was first marketed in 1989, and since then fluoxetine has become the most widely prescribed antidepressant. Even though it was claimed earlier that fluoxetine has little or no effect on reducing seizure threshold, its association with seizure activity is being increasingly recognized. Results: We report a case of 53 year old depressed male with no apparent risk factors, treated with 20mg of fluoxetine for 3 weeks, experienced a seizure. Conclusion: Clinician should be aware that seizure and the cardiac dysrythmias have been reported in the literature, the risk of seizures depends on important critical factors like an individual’s predisposing factors, followed by the amount and rate of dosage titration, and the relative epileptogenic potential of the particular drug.